Immunogen
Synthesized peptide derived from human TRM6 AA range: 175-225
Specificity
This antibody detects endogenous levels of TRM6 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Function
function:Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TRM6/GCD10 family.,subunit:tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of trm6 and trm61.,tissue specificity:Expressed in brain, liver, testis and ovary.,
Gene Name
TRMT6 KIAA1153 TRM6 CGI-09
Human protein sequence Database
Q9UJA5
Mouse protein sequence database
Q8CE96
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in brain, liver, testis and ovary.
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