Immunogen
Synthesized peptide derived from human NKD2 AA range: 311-361
Specificity
This antibody detects endogenous levels of NKD2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012],
Function
developmental stage:Expressed in fetal kidney and lung.,function:Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.,similarity:Belongs to the NKD family.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with DVL1, DVL2, DVL3 and PPP2R3A (By similarity). Interacts with TGFA.,tissue specificity:Expressed in kidney, lung, pancreas and spleen.,
Fields
>>Wnt signaling pathway;>>Hippo signaling pathway
Human protein sequence Database
Q969F2
Mouse protein sequence database
Q8VE28
Rat protein sequence database
Cellular localization
Cell membrane . Cytoplasm . Cytoplasmic vesicle .
Tissue expression
Expressed in kidney, lung, pancreas and spleen.
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