Immunogen
Synthesized peptide derived from human RPH3L AA range: 162-212
Specificity
This antibody detects endogenous levels of RPH3L at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010],
Function
domain:The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A.,function:Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RabBD (Rab-binding) domain.,subcellular location:Recruited to the vesicle membrane in a GTP-and RAB3B-dependent manner in epithelial cells.,subunit:Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX.,tissue specificity:Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells.,
Human protein sequence Database
Q9UNE2
Mouse protein sequence database
Q768S4
Rat protein sequence database
O54880
Cellular localization
Cytoplasm . Cytoplasmic vesicle, secretory vesicle membrane . Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells.
Tissue expression
Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车