Immunogen
Synthesized peptide derived from human SC6A9 AA range: 101-151
Specificity
This antibody detects endogenous levels of SC6A9 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016],
Function
function:Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,tissue specificity:All GLYT-1 subtypes can be found in brain, kidney, pancreas, lung, placenta, liver. But GLYT-1C subtype is only found in the brain.,
Fields
>>Synaptic vesicle cycle
Human protein sequence Database
P48067
Mouse protein sequence database
P28571
Rat protein sequence database
P28572
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.
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