Immunogen
Synthesized peptide derived from human FIBP AA range: 104-154
Specificity
This antibody detects endogenous levels of FIBP at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:May be involved in mitogenic function of FGF1.,subcellular location:Also associated with cytoplasmic membranes, particularly of mitochondria.,subunit:Binds to internalized FGF1.,tissue specificity:Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.,
Human protein sequence Database
O43427
Mouse protein sequence database
Q9JI19
Rat protein sequence database
Cellular localization
Nucleus. Endomembrane system; Peripheral membrane protein. Also associated with cytoplasmic membranes, particularly of mitochondria.
Tissue expression
Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.
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