Immunogen
Synthesized peptide derived from human ZRAN1 AA range: 255-305
Specificity
This antibody detects endogenous levels of ZRAN1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
domain:The OTU domain mediates the deubiquitinating activity.,domain:The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin.,function:Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. May also modulate TNF-alpha signaling.,similarity:Belongs to the peptidase C64 family.,similarity:Contains 1 OTU domain.,similarity:Contains 3 RanBP2-type zinc fingers.,subunit:Interacts with APC and TRAF6.,tissue specificity:Widely expressed.,
Human protein sequence Database
Q9UGI0
Mouse protein sequence database
Q7M760
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Enriched in punctate localization in the cytoplasm. .
Tissue expression
Widely expressed.
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