Immunogen
Synthesized peptide derived from human TFCP2 AA range: 21-71
Specificity
This antibody detects endogenous levels of TFCP2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010],
Function
developmental stage:Expressed in fetal erythroid tissue.,function:Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.,miscellaneous:In PubMed:8114710 authors noted that a 10-fold molar excess of isoform 2 over isoform 1 inhibited DNA-binding.,similarity:Belongs to the grh/CP2 family. CP2 subfamily.,subunit:Binds to DNA as a dimer, isoform 2 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP
Human protein sequence Database
Q12800
Mouse protein sequence database
Q9ERA0
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).
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