Immunogen
Synthesized peptide derived from human CMYA5 AA range: 3866-3916
Specificity
This antibody detects endogenous levels of CMYA5 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
domain:Amphipathic helix regions act as an anchoring domain for PKA, and appear to be responsible of the interaction between myospryn and PRKAR2A.,induction:Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD).,sequence caution:Contaminating sequence. Potential poly-A sequence.,sequence caution:Translated as Trp.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Found predominantly at the periphery of the nucleus but also throughout the cell. Localized at the Z-line costamere connection level of the sarcolemma and in lysosomes.,subunit:Interacts with ACTN2, DTNBP1/dysbindin and PRKAR2A (By similarity). Interacts with DES.,tissue specificity:Expressed in skeletal muscle; at a strong level and in heart.,
Gene Name
CMYA5 C5orf10 DTNBP2 SPRYD2 TRIM76
Human protein sequence Database
Q8N3K9
Mouse protein sequence database
Q70KF4
Rat protein sequence database
Cellular localization
Nucleus . Sarcoplasmic reticulum . Cytoplasm . Cytoplasm, perinuclear region . Cytoplasm, myofibril, sarcomere, M line . Found predominantly at the periphery of the nucleus but also throughout the cell. Localized in lysosomes (By similarity). In skeletal muscles, localizes along myofiber periphery, at costameres (By similarity). Predominantly flanks Z-disks (By similarity). Occasionally present at the M-band level. Colocalized with RYR2 in the sarcoplasmic reticulum (By similarity). .
Tissue expression
Expressed in skeletal muscle; at a strong level and in heart.
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