Immunogen
Synthesized peptide derived from human DET1 AA range: 48-98
Specificity
This antibody detects endogenous levels of DET1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.,similarity:Belongs to the DET1 family.,subunit:Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1.,tissue specificity:Highly expressed in the ovary, some lymphoid organs and resting leukocytes.,
Fields
>>Ubiquitin mediated proteolysis
Human protein sequence Database
Q7L5Y6
Mouse protein sequence database
Q9D0A0
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Highly expressed in the ovary, some lymphoid organs and resting leukocytes.