Immunogen
Synthesized peptide derived from human XPO6 AA range: 204-254
Specificity
This antibody detects endogenous levels of XPO6 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012],
Function
function:Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.,similarity:Belongs to the exportin family.,similarity:Contains 1 importin N-terminal domain.,subcellular location:Shuttles between the nucleus and the cytoplasm.,subunit:Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner.,
Gene Name
XPO6 KIAA0370 RANBP20
Fields
>>Nucleocytoplasmic transport
Human protein sequence Database
Q96QU8
Mouse protein sequence database
Q924Z6
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Shuttles between the nucleus and the cytoplasm. .
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