Immunogen
Synthesized peptide derived from human SDHL AA range: 207-257
Specificity
This antibody detects endogenous levels of SDHL at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008],
Function
catalytic activity:L-serine = pyruvate + NH(3).,cofactor:Pyridoxal phosphate.,pathway:Carbohydrate biosynthesis; gluconeogenesis.,similarity:Belongs to the serine/threonine dehydratase family.,subunit:Homodimer.,
Fields
>>Glycine, serine and threonine metabolism;>>Cysteine and methionine metabolism;>>Valine, leucine and isoleucine biosynthesis;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids
Human protein sequence Database
P20132
Mouse protein sequence database
Q8VBT2
Rat protein sequence database
P09367
Cellular localization
Cytoplasm.
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