Immunogen
Synthesized peptide derived from human CNOT6 AA range: 293-343
Specificity
This antibody detects endogenous levels of CNOT6 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014],
Function
cofactor:Magnesium.,function:Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex.,similarity:Belongs to the CCR4/nocturin family.,similarity:Contains 3 LRR (leucine-rich) repeats.,subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Interacts with UNR.,
Gene Name
CNOT6 CCR4 KIAA1194
Human protein sequence Database
Q9ULM6
Mouse protein sequence database
Q8K3P5
Rat protein sequence database
Q6AXU9
Cellular localization
Cytoplasm . Nucleus . Predominantly cytoplasmic. .
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