Immunogen
Synthesized peptide derived from human I5P2 AA range: 292-342
Specificity
This antibody detects endogenous levels of I5P2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014],
Function
catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,function:Hydrolyzes the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.,similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Platelets.,
Fields
>>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system
Human protein sequence Database
P32019
Mouse protein sequence database
Q8K337
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Endoplasmic reticulum-Golgi intermediate compartment . Early endosome membrane . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle, phagosome membrane . Golgi apparatus .
Tissue expression
Platelets.
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