Immunogen
Synthesized peptide derived from human SRGP1 AA range: 159-209
Specificity
This antibody detects endogenous levels of SRGP1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016],
Function
function:GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.,sequence caution:Intron retention.,similarity:Contains 1 FCH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with ROBO1, CDC42 and RHOA.,tissue specificity:Expressed in brain, lung, kidney, and testis.,
Gene Name
SRGAP1 ARHGAP13 KIAA1304
Human protein sequence Database
Q7Z6B7
Mouse protein sequence database
Q91Z69
Rat protein sequence database
Cellular localization
cytoplasm,cytosol,
Tissue expression
Expressed in brain, lung, kidney, and testis.
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