Immunogen
Synthesized peptide derived from human UN13B AA range: 1325-1375
Specificity
This antibody detects endogenous levels of UN13B at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008],
Function
domain:The C2 domains are not involved in calcium-dependent phospholipid binding.,function:Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.,similarity:Belongs to the unc-13 family.,similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 MHD2 (MUNC13 homology domain 2) domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 3 C2 domains.,subcellular location:Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.
Fields
>>Synaptic vesicle cycle
Human protein sequence Database
O14795
Mouse protein sequence database
Q9Z1N9
Rat protein sequence database
Q62769
Cellular localization
Cytoplasm . Membrane ; Peripheral membrane protein . Cell membrane . Cell junction, synapse . Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). .
Tissue expression
Expressed in kidney cortical epithelial cells and brain.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车