Molecular weight (DA)
55kD
Immunogen
Purified recombinant human CaMKIV protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of CaMKIV and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part, activity is independent on Ca(2+)/calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca(2+)/calmodulin-independent state (By similarity). Probably inactivated by serine/threonine protein phosphatase 2A.,function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role i
Other name
Brain Ca(2 ) calmodulin dependent protein kinase type 4;Brain Ca(2 ) calmodulin dependent protein kinase type IV;Brain Ca -calmodulin dependent protein kinase type IV;Calcium / calmodulin dependent protein kinase type 4 catalytic chain;Calcium / calmodulin dependent protein kinase type IV catalytic chain; Calcium/calmodulin dependent protein kinase IV;Calcium/calmodulin dependent protein kinase type IV;Calcium/calmodulin-dependent protein kinase type IV;CAM kinase 4;CAM kinase GR;CAM kinase IV;CAM kinase-GR;CaMK 4;CAMK GR;CaMK IV;CaMK4;CaMKGR;IV;KCC4_HUMAN; MGC36771.
Fields
>>Calcium signaling pathway;>>cAMP signaling pathway;>>Longevity regulating pathway;>>Apelin signaling pathway;>>Osteoclast differentiation;>>Long-term potentiation;>>Neurotrophin signaling pathway;>>Cholinergic synapse;>>Oxytocin signaling pathway;>>Aldosterone synthesis and secretion;>>Amphetamine addiction;>>Alcoholism;>>Glioma
Human protein sequence Database
Q16566
Mouse protein sequence database
P08414
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). .
Tissue expression
Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
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