Immunogen
Synthesized peptide derived from human ERLN2 AA range: 239-289
Specificity
This antibody detects endogenous levels of ERLN2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012],
Function
function:Plays an important role in the early steps of the endoplasmic reticulum-associated degradation (ERAD) pathway. Involved in ITPR1 degradation by the ERAD pathway.,similarity:Belongs to the band 7/mec-2 family.,subcellular location:Associated with lipid raft-like domains of the endoplasmic reticulum membrane.,subunit:Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination.,tissue specificity:Ubiquitous.,
Gene Name
ERLIN2 C8orf2 SPFH2 UNQ2441/PRO5003/PRO9924
Human protein sequence Database
O94905
Mouse protein sequence database
Q8BFZ9
Rat protein sequence database
B5DEH2
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Tissue expression
Ubiquitous.
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