Immunogen
Synthesized peptide derived from human PI42C AA range: 262-312
Specificity
This antibody detects endogenous levels of PI42C at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.,function:May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.,PTM:Phosphorylated.,similarity:Contains 1 PI5K domain.,subcellular location:Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis.,
Gene Name
PIP4K2C PIP5K2C
Fields
>>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system;>>Regulation of actin cytoskeleton
Human protein sequence Database
Q8TBX8
Mouse protein sequence database
Q91XU3
Rat protein sequence database
O88370
Cellular localization
Endoplasmic reticulum . Cytoplasm .
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