Immunogen
Synthesized peptide derived from human PPR17 AA range: 75-125
Specificity
This antibody detects endogenous levels of PPR17 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010],
Function
function:Inhibits protein phosphatase-2A and protein phosphatase-1.,PTM:Substrate for cGMP-dependent protein kinase.,tissue specificity:Highly expressed in cerebellum.,
Gene Name
PPP1R17 C7orf16 GSBS
Fields
>>Long-term depression
Human protein sequence Database
O96001
Mouse protein sequence database
Q9Z2E4
Rat protein sequence database
Cellular localization
intracellular,
Tissue expression
Highly expressed in cerebellum.
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