Immunogen
Synthesized peptide derived from human TYW2 AA range: 11-61
Specificity
This antibody detects endogenous levels of TYW2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008],
Function
function:Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.,pathway:tRNA modification; wybutosine-tRNA(Phe) biosynthesis.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 371.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the RNA methyltransferase trmD family. TYW2 subfamily.,
Gene Name
TRMT12 TRM12 TYW2
Human protein sequence Database
Q53H54
Mouse protein sequence database
Q8BG71
Rat protein sequence database
Q4V8B8
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