Immunogen
Synthesized peptide derived from human RAB3A AA range: 27-77
Specificity
This antibody detects endogenous levels of RAB3A at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.,similarity:Belongs to the small GTPase superfamily. Rab family.,subunit:Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3.,tissue specificity:Specifically expressed in brain.,
Fields
>>Synaptic vesicle cycle;>>Insulin secretion
Human protein sequence Database
P20336
Mouse protein sequence database
P63011
Rat protein sequence database
P63012
Cellular localization
Cytoplasm, cytosol . Lysosome . Cytoplasmic vesicle, secretory vesicle . Cell projection, axon . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell junction, synapse, presynapse . Cell junction, synapse, postsynapse . Cycles between a vesicle-associated GTP-bound form and a cytosolic GDP-bound form. .
Tissue expression
Specifically expressed in brain.
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