Immunogen
Synthesized peptide derived from human PP12C AA range: 542-592
Specificity
This antibody detects endogenous levels of PP12C at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],
Function
caution:Although assigned as two separate genes (PPP1R12C and LENG3), it is probable that LENG3 does not exist by itself and is a part of the PPP1R12C gene.,function:Regulates myosin phosphatase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Unspliced mRNA.,similarity:Contains 4 ANK repeats.,subcellular location:Along actomyosin filaments and stress fibers.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.,tissue specificity:Ubiquitously expressed. Highly expressed in heart.,
Gene Name
PPP1R12C LENG3 MBS85
Fields
>>Vascular smooth muscle contraction;>>Focal adhesion;>>Regulation of actin cytoskeleton;>>Oxytocin signaling pathway;>>Proteoglycans in cancer
Human protein sequence Database
Q9BZL4
Mouse protein sequence database
Q3UMT1
Rat protein sequence database
Cellular localization
Cytoplasm . Cytoplasm, cytoskeleton, stress fiber .
Tissue expression
Ubiquitously expressed. Highly expressed in heart.
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