Immunogen
Synthesized peptide derived from human RHBT2 AA range: 573-623
Specificity
This antibody detects endogenous levels of RHBT2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
Function
similarity:Belongs to the small GTPase superfamily. Rho family.,similarity:Contains 2 BTB (POZ) domains.,tissue specificity:Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain.,
Gene Name
RHOBTB2 DBC2 KIAA0717
Fields
>>Ubiquitin mediated proteolysis
Human protein sequence Database
Q9BYZ6
Mouse protein sequence database
Q91V93
Rat protein sequence database
Cellular localization
intracellular,cytosol,plasma membrane,
Tissue expression
Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain.
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