Immunogen
Synthesized peptide derived from human IDI1 AA range: 103-153
Specificity
This antibody detects endogenous levels of IDI1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Isopentenyl diphosphate = dimethylallyl diphosphate.,cofactor:Binds 1 magnesium ion per subunit.,function:Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).,pathway:Isoprenoid biosynthesis; dimethylallyl-PP biosynthesis; dimethylallyl-PP from isopentenyl-PP: step 1/1.,similarity:Belongs to the IPP isomerase type 1 family.,subunit:Monomer.,
Fields
>>Terpenoid backbone biosynthesis;>>Metabolic pathways
Human protein sequence Database
Q13907
Mouse protein sequence database
P58044
Rat protein sequence database
O35760
Cellular localization
Peroxisome .
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