Immunogen
Synthesized peptide derived from human PURA1 AA range: 14-64
Specificity
This antibody detects endogenous levels of PURA1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
Function
catalytic activity:GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.,cofactor:Binds 1 magnesium ion per subunit.,function:Plays an important role in the de novo pathway of purine nucleotide biosynthesis.,pathway:Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.,similarity:Belongs to the adenylosuccinate synthetase family.,subunit:Homodimer.,tissue specificity:Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors.,
Fields
>>Purine metabolism;>>Alanine, aspartate and glutamate metabolism;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors
Human protein sequence Database
Q8N142
Mouse protein sequence database
P28650
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors.
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