Immunogen
Synthesized peptide derived from human AP3M2 AA range: 274-324
Specificity
This antibody detects endogenous levels of AP3M2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008],
Function
function:Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.,similarity:Belongs to the adaptor complexes medium subunit family.,similarity:Contains 1 MHD (mu homology) domain.,subunit:Adaptor protein complex 3 (AP-3) is an heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).,
Human protein sequence Database
P53677
Mouse protein sequence database
Q8R2R9
Rat protein sequence database
P53678
Cellular localization
Golgi apparatus. Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. .
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