Immunogen
Synthesized peptide derived from human SLIB AA range: 43-93
Specificity
This antibody detects endogenous levels of SLIB at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016],
Function
function:GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.,online information:Growth hormone releasing hormone entry,pharmaceutical:Available under the names Groliberin (Pharmacia) or Somatrel (Ferring). Also available under the name Geref (Serono). Geref is a synthetic acetylated form of residues 1 to 29 of GHRH. Used for the treatment of growth hormone deficiency.,similarity:Belongs to the glucagon family.,
Fields
>>Neuroactive ligand-receptor interaction;>>Growth hormone synthesis, secretion and action
Human protein sequence Database
P01286
Mouse protein sequence database
P16043
Rat protein sequence database
P09916
Cellular localization
Secreted.