CBX4 rabbit pAb

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Specification

BYab-12217

50UL $180 100UL $255
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Product introduction Experimental scheme Citation Related products

Product introduction>

Host

Reactiveness

Use

Molecular weight (DA)

Immunogen

Synthesized peptide derived from human CBX4 AA range: 196-246

Specificity

This antibody detects endogenous levels of CBX4 at Human/Mouse

Source

Polyclonal, Rabbit,IgG

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Dilution rate

WB 1：500-2000

Purification process (Immunogen)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Background

Function

function:E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.,pathway:Protein modification; protein sumoylation.,PTM:Phosphorylated on Thr-495 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-492.,similarity:Contains 1 chromo domain.,subunit:Interacts with histone H3-K9Me3 (By similarity). Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2

Gene Name

CBX4

Protein name

CBX4

Abbreviation

CBX4

Other name

Fields

Human gene ID

8535

Human protein sequence Database

O00257

Mouse gene ID

12418

Mouse protein sequence database

O55187

Rat gene ID

Rat protein sequence database

Cellular localization

Nucleus . Nucleus speckle . Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235). .

Tissue expression

Ubiquitous.

Storage

-20°C/1 year

Experimental scheme>

Procedure

CBX4 rabbit pAb

BYab-12217

Product introduction>

Host

Reactiveness

Use

Molecular weight (DA)

Immunogen

Specificity

Source

Formulation

Dilution rate

Purification process (Immunogen)

Concentration

Background

Function

Gene Name

Protein name

Abbreviation

Other name

Fields

Human gene ID

Human protein sequence Database

Mouse gene ID

Mouse protein sequence database

Rat gene ID

Rat protein sequence database

Cellular localization

Tissue expression

Storage

Experimental scheme>

Citation>

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CBX4 rabbit pAb

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