Immunogen
Synthesized peptide derived from human UT2 AA range: 429-479
Specificity
This antibody detects endogenous levels of UT2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011],
Function
function:Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.,induction:Isoform 1 is induced by low protein in the diet, isoform 2 by dehydration.,similarity:Belongs to the urea transporter family.,subunit:Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane.,tissue specificity:Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.,
Gene Name
SLC14A2 HUT2 UT2
Human protein sequence Database
Q15849
Mouse protein sequence database
Q8R4T9
Rat protein sequence database
Q62668
Cellular localization
Apical cell membrane; Multi-pass membrane protein.
Tissue expression
Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.
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