Immunogen
Synthesized peptide derived from human RIMB1 AA range: 24-74
Specificity
This antibody detects endogenous levels of RIMB1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
caution:PubMed:9915832 demonstrated interaction with BZRP but later PubMed:12435798 demonstrated in the rat ortholog that is not associated with BZRP in the brain.,domain:The SH3 and proline-rich domain is required for the interaction with BZRP and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2.,similarity:Belongs to the RIMBP family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 3 SH3 domains.,subcellular location:Preferentially expressed in the mitochondria in the presence of BZRP.,subunit:Interacts with RIMS1 and RIMS2 (By similarity). Interacts with BZRP.,tissue specificity:Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level
Gene Name
BZRAP1 KIAA0612 RBP1 RIMBP1
Human protein sequence Database
O95153
Mouse protein sequence database
Q7TNF8
Rat protein sequence database
Q9JIR0
Cellular localization
Cytoplasm . Mitochondrion . Preferentially expressed in the mitochondria in the presence of TSPO.
Tissue expression
Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus.
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