Immunogen
Synthesized peptide derived from human SUV3 AA range: 443-493
Specificity
This antibody detects endogenous levels of SUV3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
cofactor:Magnesium or manganese.,enzyme regulation:Helicase activity toward DNA substrate is inhibited by micromolar concentrations of 5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded nucleoside analogs.,function:ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction. May protect cells from apoptosis.,similarity:Belongs to the helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:Interacts with HBXIP.,tissue specificity:Broadly expressed.,
Human protein sequence Database
Q8IYB8
Mouse protein sequence database
Q80YD1
Rat protein sequence database
Q5EBA1
Cellular localization
Nucleus . Mitochondrion matrix . Mitochondrion matrix, mitochondrion nucleoid .
Tissue expression
Broadly expressed.
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