Immunogen
Synthesized peptide derived from human cadherin
Specificity
The antibody can recognize many isotypes of cadherin including E-cadherin, N-cadherin, P-cadherin and R-cadherin. In western blotting of A431 and MCF7 cell lysates, the antibody can label a 130KDa b
Source
Mouse, Monoclonal/IgG2a, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.89% sodium azide.
Dilution rate
IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Abbreviation
cadherin pan
Fields
>>Rap1 signaling pathway;>>Apelin signaling pathway;>>Hippo signaling pathway;>>Cell adhesion molecules;>>Adherens junction;>>Bacterial invasion of epithelial cells;>>Pathways in cancer;>>Endometrial cancer;>>Thyroid cancer;>>Melanoma;>>Bladder cancer;>>Gastric cancer
Human protein sequence Database
P12830/P19022/P22223/P55283
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell junction, adherens junction . Cell membrane ; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Tissue expression
Non-neural epithelial tissues.
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