Immunogen
Synthesized peptide derived from human RN213. AA range:307-407
Specificity
This antibody detects endogenous levels of RN213 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],
Function
disease:A chromosomal aberration involving ALO17 is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALK.,sequence caution:Translated as Gln.,similarity:Contains 1 RING-type zinc finger.,
Gene Name
RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR
Human protein sequence Database
Q63HN8
Mouse protein sequence database
E9Q555
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Lipid droplet .
Tissue expression
Widely expressed (at protein level). ; [Isoform 1]: Major isoform detected in all tissues examined. ; [Isoform 2]: Minor isoform with restricted expression.
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