Immunogen
Synthesized peptide derived from human FGF-19
Specificity
This antibody detects endogenous levels of Human FGF-19
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
function:May be involved in brain development during embryogenesis.,miscellaneous:Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Expressed in fetal brain, cartilage, retina, and adult gall bladder.,
Function
ameboidal cell migration, neural crest cell migration, cell motion, heart development, negative regulation of biosynthetic process, positive regulation of signal transduction, regulation of cellular ketone metabolic process,regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of glucose transport, positive regulation of glucose transport, negative regulation of steroid biosynthetic process, mesenchymal cell development, neural crest cell development, neural crest cell differentiation,cell migration, regulation of lipid metabolic process, regulation of steroid metabolic process, negative regulation of cellular biosynthetic process, regulation of MAPKKK cascade, positive regulation of MAPKKK cascade, negative regulation of lipid metabolic process, negative regulation of steroid metabolic process, regulati
Gene Name
FGF19 UNQ334/PRO533
Other name
Fibroblast growth factor 19 (FGF-19)
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Regulation of actin cytoskeleton;>>Pathways in cancer;>>Melanoma;>>Breast cancer;>>Gastric cancer
Human protein sequence Database
O95750
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed in fetal brain, cartilage, retina, and adult gall bladder.
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