Immunogen
Purified recombinant fragment of human KLHL13 expressed in E. Coli.
Specificity
KLHL13 Monoclonal Antibody detects endogenous levels of KLHL13 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
Function
function:Substrate-specific adapter for a CUL3-based E3 ubiquitin-protein ligase complex. Within this complex, controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BACK (BTB/Kelch associated) domain.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Forms a complex with CUL3 and KLHL9. Interacts with AURKB. Interacts with CUL3.,
Protein name
Kelch-like protein 13
Other name
KLHL13; BKLHD2; KIAA1309; Kelch-like protein 13; BTB and kelch domain-containing protein 2
Fields
>>Ubiquitin mediated proteolysis
Human protein sequence Database
Q9P2N7
Mouse protein sequence database
Q80TF4
Rat protein sequence database
Cellular localization
midbody,Cul3-RING ubiquitin ligase complex,
Tissue expression
Brain,Testis,Thalamus,Whole embryo,
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