Immunogen
Purified recombinant fragment of human KLHL21 expressed in E. Coli.
Specificity
KLHL21 Monoclonal Antibody detects endogenous levels of KLHL21 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
function:Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BACK (BTB/Kelch associated) domain.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Interacts with cul3.,
Function
function:Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BACK (BTB/Kelch associated) domain.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Interacts with cul3.,
Protein name
Kelch-like protein 21
Other name
KLHL21; KIAA0469; Kelch-like protein 21
Human protein sequence Database
Q9UJP4
Mouse protein sequence database
Q3U410
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, spindle . Localizes to the spindle midzone and targets CUL3 to this region.
Tissue expression
Brain,Hepatoma,Hippocampus,Lung carcinoma,PCR rescued clones,Spleen,
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