Molecular weight (DA)
52kD
Immunogen
Purified recombinant human CHRDL1 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of CHRDL1 and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb 1:1000 IHC-p 1:300 icc 1:300
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009],
Function
function:Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.,induction:By hypoxia in retinal pericytes.,similarity:Contains 3 VWFC domains.,tissue specificity:Expressed in retinal pericytes.,
Other name
CHL;chordin like 1;Chordin-like protein 1;CHRDL1;CRDL1_HUMAN;dA141H5.1;neuralin 1; Neuralin-1;Neurogenesin-1;NRLN1;Ventroptin;VOPT.
Human protein sequence Database
Q9BU40
Mouse protein sequence database
Q920C1
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.
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