Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DNAJC5. AA range:131-180
Specificity
CSP Polyclonal Antibody detects endogenous levels of CSP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010],
Function
function:May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,similarity:Contains 1 J domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.,
Protein name
DnaJ homolog subfamily C member 5
Other name
DNAJC5; CSP; DnaJ homolog subfamily C member 5; Cysteine string protein; CSP
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q9H3Z4
Mouse protein sequence database
P60904
Rat protein sequence database
P60905
Cellular localization
Cytoplasm, cytosol . Membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane . Melanosome . Cell membrane . The association with membranes is regulated by palmitoylation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
Tissue expression
Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
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