Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NMU. AA range:125-174
Specificity
Neuromedin-U Polyclonal Antibody detects endogenous levels of Neuromedin-U protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015],
Function
function:Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.,similarity:Belongs to the NmU family.,tissue specificity:Expressed throughout the enteric nervous system with highest levels being found in the jejunum.,
Protein name
Neuromedin-U
Abbreviation
Neuromedin-U
Other name
NMU; Neuromedin-U
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P48645
Mouse protein sequence database
Q9QXK8
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed throughout the enteric nervous system with highest levels being found in the jejunum.
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