Immunogen
The antiserum was produced against synthesized peptide derived from human PDZD2. AA range:51-100
Specificity
PDZK3 Polyclonal Antibody detects endogenous levels of PDZK3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015],
Function
disease:May be associated with the early promotion of prostate tumoregenesis.,PTM:A secreted form is produced by caspase-mediated proteolytic cleavage.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 6 PDZ (DHR) domains.,subcellular location:At cell-cell contacts in lung epithelial cells.,subunit:Interacts with SCN10A, CTNND2 and PKP4.,tissue specificity:Expressed (at protein level) in prostate and many prostate tumors.,
Protein name
PDZ domain-containing protein 2
Other name
PDZD2; AIPC; KIAA0300; PDZK3; PDZ domain-containing protein 2; Activated in prostate cancer protein; PDZ domain-containing protein 3
Human protein sequence Database
O15018
Mouse protein sequence database
Rat protein sequence database
Q9QZR8
Cellular localization
Nucleus . Cytoplasm . Endoplasmic reticulum . At cell-cell contacts in lung epithelial cells. .; [Processed PDZ domain-containing protein 2]: Secreted .
Tissue expression
Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.
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