Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PGD. AA range:71-120
Specificity
PGD Polyclonal Antibody detects endogenous levels of PGD protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p: 100-300.WB: 1/500 - 1/2000. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],
Function
catalytic activity:6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.,pathway:Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.,similarity:Belongs to the 6-phosphogluconate dehydrogenase family.,subunit:Homodimer.,
Protein name
6-phosphogluconate dehydrogenase decarboxylating
Other name
PGD; PGDH; 6-phosphogluconate dehydrogenase; decarboxylating
Fields
>>Pentose phosphate pathway;>>Glutathione metabolism;>>Metabolic pathways;>>Carbon metabolism
Human protein sequence Database
P52209
Mouse protein sequence database
Q9DCD0
Rat protein sequence database
P85968
Cellular localization
Cytoplasm .
Tissue expression
Heart,Lung,
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