Molecular weight (DA)
38kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DNAJB4. AA range:91-140
Specificity
DnaJB4 Polyclonal Antibody detects endogenous levels of DnaJB4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
Function
induction:By heat shock.,similarity:Contains 1 J domain.,
Protein name
DnaJ homolog subfamily B member 4
Other name
DNAJB4; DNAJW; HLJ1; DnaJ homolog subfamily B member 4; Heat shock 40 kDa protein 1 homolog; HSP40 homolog; Heat shock protein 40 homolog; Human liver DnaJ-like protein
Human protein sequence Database
Q9UDY4
Mouse protein sequence database
Q9D832
Rat protein sequence database
Cellular localization
Cytoplasm . Cell membrane . Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.
Tissue expression
Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.
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