Immunogen
Synthesized peptide derived from the Internal region of human Slit3.
Specificity
Slit3 Polyclonal Antibody detects endogenous levels of Slit3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],
Function
function:May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.,sequence caution:Intron retention.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 23 LRR (leucine-rich) repeats.,similarity:Contains 9 EGF-like domains.,tissue specificity:Predominantly expressed in thyroid.,
Protein name
Slit homolog 3 protein
Other name
SLIT3; KIAA0814; MEGF5; SLIL2; Slit homolog 3 protein; Slit-3; Multiple epidermal growth factor-like domains protein 5; Multiple EGF-like domains protein 5
Human protein sequence Database
O75094
Mouse protein sequence database
Q9WVB4
Rat protein sequence database
O88280
Cellular localization
Secreted .
Tissue expression
Predominantly expressed in thyroid.
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