Molecular weight (DA)
46kD
Immunogen
The antiserum was produced against synthesized peptide derived from human 5-HT-1A. AA range:291-340
Specificity
SR-1A Polyclonal Antibody detects endogenous levels of SR-1A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012],
Function
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
5-hydroxytryptamine receptor 1A
Other name
HTR1A; ADRB2RL1; ADRBRL1; 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; G-21; Serotonin receptor 1A
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Serotonergic synapse;>>Taste transduction
Human protein sequence Database
P08908
Mouse protein sequence database
Q64264
Rat protein sequence database
P19327
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite .
Tissue expression
Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
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