Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SSTR4. AA range:155-204
Specificity
SSTR4 Polyclonal Antibody detects endogenous levels of SSTR4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008],
Function
function:Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.,
Protein name
Somatostatin receptor type 4
Other name
SSTR4; Somatostatin receptor type 4; SS-4-R; SS4-R; SS4R
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P31391
Mouse protein sequence database
P49660
Rat protein sequence database
P30937
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
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