Molecular weight (DA)
61kD
Immunogen
The antiserum was produced against synthesized peptide derived from human APBA3. AA range:361-410
Specificity
X11γ Polyclonal Antibody detects endogenous levels of X11γ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
amyloid beta precursor protein binding family A member 3(APBA3) Homo sapiens The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease. [provided by RefSeq, Jul 2008],
Function
domain:Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.,function:May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PID domain.,similarity:Contains 2 PDZ (DHR) domains.,subunit:Binds to the cytoplasmic domain of amyloid protein (APP) in vivo.,tissue specificity:Expressed in all the tissues examined with lower levels in brain and testis.,
Protein name
Amyloid beta A4 precursor protein-binding family A member 3
Other name
APBA3; MINT3; X11L2; Amyloid beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; Mint-3
Human protein sequence Database
O96018
Mouse protein sequence database
O88888
Rat protein sequence database
Cellular localization
Cytoplasm, perinuclear region .
Tissue expression
Expressed in all tissues examined with lower levels in brain and testis.
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