Molecular weight (DA)
100kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human NRP2. AA range:791-840
Specificity
Neuropilin-2 Polyclonal Antibody detects endogenous levels of Neuropilin-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
Function
function:High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.,similarity:Belongs to the neuropilin family.,similarity:Contains 1 MAM domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 F5/8 type C domains.,subunit:Heterodimer with NRP1 (Probable). Binds PLXNB1.,
Protein name
Neuropilin-2
Abbreviation
Neuropilin-2
Other name
NRP2; VEGF165R2; Neuropilin-2; Vascular endothelial cell growth factor 165 receptor 2
Human protein sequence Database
O60462
Mouse protein sequence database
O35375
Rat protein sequence database
O35276
Cellular localization
Membrane ; Single-pass type I membrane protein .; [Isoform s9]: Secreted .
Tissue expression
Brain,Human endometrium carcinoma cell line,Liver,Mammary gland,Ovary,Prostate adenocarcino
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