Molecular weight (DA)
16kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human PSPN. AA range:101-150
Specificity
PSP Polyclonal Antibody detects endogenous levels of PSP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
persephin(PSPN) Homo sapiens This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016],
Function
function:Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.,similarity:Belongs to the TGF-beta family. GDNF subfamily.,subunit:Homodimer; disulfide-linked.,
Other name
PSPN; Persephin; PSP
Human protein sequence Database
O60542
Mouse protein sequence database
O70300
Rat protein sequence database
O70301
Cellular localization
Secreted.
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