Molecular weight (DA)
66kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human STRA8. AA range:151-200
Specificity
Stra8 Polyclonal Antibody detects endogenous levels of Stra8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010],
Function
function:Required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase.,PTM:Phosphorylated.,tissue specificity:Expressed specifically in testis.,
Protein name
Stimulated by retinoic acid gene 8 protein homolog
Other name
STRA8; Stimulated by retinoic acid gene 8 protein homolog
Human protein sequence Database
Q7Z7C7
Mouse protein sequence database
P70278
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent. .
Tissue expression
Expressed specifically in testis and fetal ovaries.
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