Molecular weight (DA)
66kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IGFALS. AA range:303-352
Specificity
ALS Polyclonal Antibody detects endogenous levels of ALS protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
Function
function:Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.,similarity:Contains 20 LRR (leucine-rich) repeats.,subunit:Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.,tissue specificity:Plasma.,
Protein name
Insulin-like growth factor-binding protein complex acid labile subunit
Other name
IGFALS; ALS; Insulin-like growth factor-binding protein complex acid labile subunit; ALS
Fields
>>Growth hormone synthesis, secretion and action
Human protein sequence Database
P35858
Mouse protein sequence database
P70389
Rat protein sequence database
Cellular localization
Secreted, extracellular space.
Tissue expression
Plasma.
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